The colony prospered. Tobacco—grown by indentured servants and enslaved Africans—sustained the economy. The first popularly elected legislative body in the New World was established. Following the failed Indian uprising in 1622 and on orders from London, the native peoples were “removed” and reduced in number to 3,000 by a “War of Extermination.” During the next hundred years, the remainder of Virginia’s population expanded a hundred fold. Social inequalities, however, and frontier conflicts with the French and with Indians made this distant dominion increasingly difficult to govern from London.